462 DEFINING IMPACT OF PRE-OPERATIVE ANAEMIA ON SURVIVAL IN OESOPHAGOGASTRIC CANCER: A MULTI-INSTITUTIONAL ANALYSIS. (14th September 2020)

• Record Type: Journal Article
• Authors: Kamarajah, S; Khaw, R; Chmelo, J; Navidi, M; Phillips, A
• Is Part Of: Diseases of the esophagus. Volume 33(2020)Supplement 1
• Publication Date: 2020-09-14
• Subjects: Esophagus -- Diseases -- Periodicals; 616.32
• DOI: 10.1093/dote/doaa087.118
• Languages: English
• ISSNs: 1120-8694

Abstract

Abstract: : Growing interest surrounding pre-operative anaemia in patiens undergoing major surgery. However, no current evidence surrounding role of pre-operative anaemia on the post-operative outcomes and long-term survival following esophagectomy for esophageal cancers. This study aimed to evaluate morbidity and mortality according to pre-operative in patients undergoing esophagectomy for esophageal cancer. Methods: Consecutive patients undergoing esophagectomy for esophageal cancers (adenocarcinoma or squamous cell carcinoma) between January 2000 and December 2018 at the Northern Oesophagogastric Unit were included from a prospectively maintained database. The main explanatory variable is pre-operative anaemia. Primary outcome was overall survival. Secondary outcomes include overall complications, anastomotic leaks and pulmonary complications. Results: During the study period, 1148 patients underwent esophagectomy for cancer. Of these 7% (n = 78) had pre-operative anaemia. Median survival of patients with anaemia were similar to those without pre-operative anaemia (median: 67 vs 45, p = 0.1). On Cox multivariable regression analysis, pre-operative anaemia had no impact on long-term survival, even when stratified for oesophageal adenocarcinoma and squamous cell carcinoma. Rates of overall complications (71% vs 66%), anastomotic leaks (4% vs 8%) and pulmonary complications (19% vs 14%) were similar between the groups. Conclusion: Contrary to published evidence in cardiothoracic and vascular surgery, pre-operative anaemia had no impact on long-term survival and post-operative outcomes for esophagectomy.