405 TUMOR BUDDING AS A PROGNOSTIC MARKER FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA. (14th September 2020)

• Record Type: Journal Article
• Authors: Suresh, A; Nag, A; S, R; M, A
• Is Part Of: Diseases of the esophagus. Volume 33(2020)Supplement 1
• Publication Date: 2020-09-14
• Subjects: Esophagus -- Diseases -- Periodicals; 616.32
• DOI: 10.1093/dote/doaa087.99
• Languages: English
• ISSNs: 1120-8694

Abstract

Abstract: : Carcinomas of the esophagus are the sixth most common malignancy worldwide in males. Esophageal cancer occurs in two histological types: SCC and adenocarcinoma, 90% is SCC in developing countries. The presence of tumor budding (TB) at the tumor–host interface of gastrointestinal cancers has been recognized as a hallmark of unfavorable disease biology. TB is defined as the presence of isolated malignant cells or small clusters of up to five cells at the tumor invasive front. Methods: The study done by taking formalin fixed paraffin blocks of 13 esophagectomy specimens from the year 2014-2019. TB score was calculated at the invasive front of the tumor in 200x magnification. 10 fileds were screened and a hotspot was found. <5 buds were taken as a low grade budding. ≥5 buds were taken as a high grade budding. Results: The study showed that 53.85% were found to be males & 46.15% were females. In pT staging, T3 was the most common. 61.5% of the cases showed high grade budding while low grade budding was seen in only 38.5%. This tells us 69.2% fell under T3 stage of which 88.89% had high grade TB while only 11.11% had low grade budding. Of the 4 present cases of LVI, 75% had high grade TB & 25% had low grade budding. Of the 3 margin involved cases, 67% had high grade TB while 33% had low grade budding. Conclusion: To conclude, TB is a valuable prognostic factor and indicator of aggressive diseases. Presence of TB correlates to unfavorable clinico-pathological features. It also provides an important value of risk stratification. 1. Risk stratification 2. High grade TB benefit from esophagectomy.