Interactions Between Sugar-Sweetened Beverage Consumption and Genetic Variants in the ChREBP Locus on Lipoprotein Concentrations in the UK Biobank: A Replication Study. (29th May 2020)

• Record Type: Journal Article
• Authors: Guirette, Melanie; Haslam, Danielle; Peloso, Gina; Pitsillides, Achilleas; Smith, Caren; Dupuis, Josee; Dashti, Hassan; Lichtenstein, Alice; Herman, Mark; McKeown, Nicola
• Is Part Of: Current developments in nutrition. Volume 4(2020)Supplement 2
• Page Start: 1255
• Page End: 1255
• Publication Date: 2020-05-29
• Subjects: Nutrition -- Periodicals; Nutritional Physiological Phenomena; Nutrition; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 612.3
• DOI: 10.1093/cdn/nzaa058_013
• Languages: English
• ISSNs: 2475-2991

Abstract

Abstract: Objectives: A meta-analysis of 11 CHARGE cohorts ( N = 63, 599) suggested that genetic variants within or near the CHREBP locus may modify the associations between sugar sweetened beverage (SSB) consumption and high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) concentrations. The study objective was to replicate these findings in a large independent cohort. Methods: Blood lipids and 24-hour recalls were available for 57, 794 adults of European ancestry in the UK Biobank (2006-'10). SSBs included "squash" and "fizzy" drinks derived from a single 24-hr recall. A total of 875 SNPs within or near the CHREBP locus were identified and included in this analysis. Associations between these SNPs and HDL-C and TG concentrations were quantified among participants who did not report SSB consumption (non-consumers, n = 45, 866), reported ≥0.5 servings/day of SSB (consumers, n = 11, 928), and a subset of consumers who reported ≥2 servings/day of SSB (high consumers, n = 3742). Interaction between SSB and selected SNPs on HDL-C and TG concentrations was evaluated by examining the difference in beta coefficients between strata. Results were considered statistically significant at a Bonferroni-corrected p interact < 0.0001 (0.05/499 effective tests). Results: A significant interaction between SSB consumption and TBL2 -rs71556729 on HDL-C concentration previously observed in the meta-analysis was replicated in UK Biobank. However, we observed a stronger interaction for a SNP in high linkage disequilibrium (R 2 = 0.93) FZD9 -rs34821369 (MAF = 0.03, pinteract = 8.2E-05) with TBL2 -rs71556729 (MAF = 0.03, pinteract = 0.0004). Among only SSB consumers, each additional minor G allele at FZD9 -rs34821369 was associated with mean HDL-C concentrations 1.63 mg/dL (SE = 0.53, P = 0.002) higher than those with the major T allele. Conclusions: Our results suggest that adults with the minor allele at FZD9 -rs34821369 may be protected against SSB-induced low HDL-C concentrations. These results are consistent the findings from a prior meta-analysis of 11 cohorts. Funding Sources: NIH, AHA, USDA-ARS. This research has been conducted using the UK Biobank Resource (Application Number 35, 835) .