A Potential Role of Interleukin 10 in COVID-19 Pathogenesis. Issue 1 (January 2021)

• Record Type: Journal Article
• Authors: Lu, Ligong; Zhang, Hui; Dauphars, Danielle J.; He, You-Wen
• Is Part Of: Trends in immunology. Volume 42:Issue 1(2021)
• Page Start: 3
• Page End: 5
• Publication Date: 2021-01
• Subjects: COVID-19 -- cytokine storm -- IL-10 -- proinflammation -- pathogenesis -- mortality -- IL-6; Immunology -- Periodicals; 571.96
• DOI: 10.1016/j.it.2020.10.012
• Languages: English
• ISSNs: 1471-4906

Abstract

Abstract : A unique feature of the cytokine storm in coronavirus disease 2019 (COVID-19) is the dramatic elevation of interleukin 10 (IL-10). This was thought to be a negative feedback mechanism to suppress inflammation. However, several lines of clinical evidence suggest that dramatic early proinflammatory IL-10 elevation may play a pathological role in COVID-19 severity.