Myeloid-derived suppressor cell and regulatory T cell frequencies in canine myasthenia gravis: A pilot study. (January 2021)

• Record Type: Journal Article
• Authors: Wu, Ying; Chang, Yu-Mei; Lawson, Brandon S.; Galban, Evelyn M.; Mittelman, Neil S.; Benedicenti, Leontine; Petesch, Scott C.; Carroll, Alicia B.; Punt, Jennifer A.; Luo, Jie; Garden, Oliver A.
• Is Part Of: Veterinary journal. Volume 267(2021)
• Publication Date: 2021-01
• Subjects: Acetylcholine receptor -- Dog -- Myasthenia gravis -- Myeloid-derived suppressor cells -- Regulatory T cells; Veterinary medicine -- Periodicals; 636
• DOI: 10.1016/j.tvjl.2020.105581
• Languages: English
• ISSNs: 1090-0233

Abstract

Highlights: Suppressor cells were assessed for the first time in dogs with myasthenia gravis Numerical alteration was not observed in myeloid-derived suppressor cells Numerical alteration was not observed in regulatory T cells No correlation was found between suppressor cell frequency and clinical course Abstract: Myasthenia gravis (MG) is a T cell-dependent, B cell-mediated autoimmune disease. Little is known about its cellular pathogenesis in dogs. This study provides the first preliminary assessment of the frequency of myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) in the peripheral blood of dogs with seropositive generalized MG. No alteration in frequency of either MDSCs or Tregs in dogs with MG was observed when compared to those in either seronegative dogs with diagnoses other than MG, or healthy dogs. A longitudinal study in three dogs with MG revealed no correlation between the relative numbers of either population and the clinical course of disease. Neither the frequency of MDSCs nor of Tregs showed a correlation with anti-AChR antibody titer in dogs with MG. These findings suggest that aberrations in the frequency of either immunosuppressive population do not occur in MG, but they need to be validated in large-scale prospective studies.