Association of Plasma β-amyloid 40 and 42 Concentration with Type 2 Diabetes Among Chinese Adults. (29th May 2020)

• Record Type: Journal Article
• Authors: Peng, Xiaobo; Xu, Zihui; Mo, Xiaoxing; Guo, Qianqian; Yin, Jiawei; Xu, Mengdai; Peng, Zhao; Sun, Taoping; Zhou, Li; Peng, Xiaolin; Xu, Shufang; Yang, Wei; Bao, Wei; Shan, Zhilei; Li, Xiaoqin; Liu, Liegang
• Is Part Of: Current developments in nutrition. Volume 4(2020)Supplement 2
• Page Start: 64
• Page End: 64
• Publication Date: 2020-05-29
• Subjects: Nutrition -- Periodicals; Nutritional Physiological Phenomena; Nutrition; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 612.3
• DOI: 10.1093/cdn/nzaa040_064
• Languages: English
• ISSNs: 2475-2991

Abstract

Abstract: Objectives: We aimed to investigate the association of plasma β-amyloid (Aβ) 40 and Aβ42 with risk of type 2 diabetes. Methods: We performed a case-control study and a nested case-control study within a prospective cohort study. In the case-control study, we included 1063 newly diagnosed type 2 diabetes cases and 1063 controls matched by age and sex. In the nested case-control study, we included 121 incident type 2 diabetes cases and 242 matched controls. Plasma Aβ40 and Aβ42 concentrations were simultaneously measured with electrochemiluminescence immunoassay. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression with adjustment for age, sex, BMI, current smoking status, current drinking status, physical activity, family history of diabetes, and hypertension. Results: In the case-control study, the multivariable-adjusted ORs of type 2 diabetes comparing the highest with the lowest quartile of plasma Aβ concentrations were 1.97 (95% CI: 1.46, 2.66) for plasma Aβ40 and 2.01 (95% CI: 1.50, 2.69) for plasma Aβ42. Each 30 ng/L increment of plasma Aβ40 was associated with 28% (95% CI: 15%, 43%) higher odds of type 2 diabetes, and each 5 ng/L increment of plasma Aβ42 was associated with 37% (95% CI: 21%, 55%) higher odds of type 2 diabetes. In the nested case-control study, the multivariable-adjusted ORs of type 2 diabetes for the highest versus the lowest quartile were 3.79 (95% CI: 1.81, 7.94) for plasma Aβ40 and 2.88 (95% CI: 1.44, 5.75) for plasma Aβ42. The multivariable-adjusted ORs of type 2 diabetes were 1.44 (95% CI: 1.18, 1.74) and 1.47 (95% CI: 1.15, 1.88) associated with each 30 ng/L increment in plasma Aβ40 and each 5 ng/L increment in plasma Aβ42, respectively. Conclusions: Our findings suggested positive associations of plasma Aβ40 and Aβ42 concentration with risk of type 2 diabetes. Further studies are warranted to elucidate the underlying mechanism and explore the potential roles of plasma Aβ in linking type 2 diabetes and Alzheimer's disease. Funding Sources: This work was funded by the National Key Research and Development Program of China, the Major International (Regional) Joint Research Project, and the National Natural Science Foundation of China.