R2TP/PAQosome as a promising chemotherapeutic target in cancer. Issue 1 (November 2020)

• Record Type: Journal Article
• Authors: Kakihara, Yoshito; Kiguchi, Tetsuo; Ohazama, Atsushi; Saeki, Makio
• Is Part Of: Japanese dental science review. Volume 56:Issue 1(2020:Feb.)
• Page Start: 38
• Page End: 42
• Publication Date: 2020-11
• Subjects: R2TP -- PAQosome -- Chaperone -- HNSCC -- OSCC -- Cancer drugs; Dentistry -- Periodicals; Dentistry -- Japan -- Periodicals; 617.6005
• DOI: 10.1016/j.jdsr.2019.08.001
• Languages: English
• ISSNs: 1882-7616

Abstract

Abstract: R2TP/PAQosome (p article for a rrangement of q uaternary structure) is a novel multisubunit chaperone specialized in the assembly/maturation of protein complexes that are involved in essential cellular processes such as PIKKs (p hosphatidyli nositol 3-k inase-like k inases) signaling, snoRNP (small nucleolar ribonucleoprotein) biogenesis, and RNAP II (RNA polymerase II) complex formation. In this review article, we describe the current understanding of R2TP/PAQosome functions and characteristics as well as how the chaperone complex is involved in oncogenesis, highlighting DNA damage response, mTOR (m ammalian t arget o f r apamycin) pathway as well as snoRNP biogenesis. Also, we discuss its possible involvement in HNSCC (h ead and n eck s quamous c ell c arcinoma) including OSCC (o ral s quamous c ell c arcinoma). Finally, we provide an overview of current anti-cancer drug development efforts targeting R2TP/PAQosome.