A facile and large-scale synthesis of a PVA/chitosan/collagen hydrogel for wound healing. (24th November 2020)

• Record Type: Journal Article
• Authors: Zhang, XiaoHui; Yin, Zhengrong; Guo, Yuqing; Huang, Haofei; Zhou, JianYe; Wang, Ling; Bai, JingYa; Fan, Zengjie
• Is Part Of: New journal of chemistry. Volume 44:Number 47(2020)
• Page Start: 20776
• Page End: 20784
• Publication Date: 2020-11-24
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d0nj04016a
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : PVA/chitosan/collagen hydrogel prepared by simple freezing and thawing method has high antibacterial properties and excellent wound healing ability. Abstract : Delayed wound healing caused by a lack of antibacterial properties and bioactivity limits the application of PVA hydrogel as a wound dressing. To break through these barriers, we developed a novel ternary hydrogel system composed of PVA, chitosan (Cs), and collagen (Col) through a facile physical cross-linking method. Based on the reasonable design and experimental verification, the synthesized PVA/Cs/Col hydrogel showed high mechanical strength, excellent antibacterial properties, and good biocompatibility. More importantly, it could effectively repair wound defects in a rat wound defect model 14 days after the operation, and the wound healing rate could reach 98.8%, which was far higher than those of other groups. Meanwhile, the healing wound tissue presented a continuous and thickened epidermis and more hair follicle structures appeared as confirmed by histological staining, further verifying its excellent repair effects on wound defects. Therefore, the facile and large-scale synthesis, low cost, and excellent repairability of the hydrogel imply its application potential in wound repair.