Binding motif of ebselen in solution: chalcogen and hydrogen bonds team up. (23rd November 2020)

• Record Type: Journal Article
• Authors: Daolio, Andrea; Scilabra, Patrick; Di Pietro, Maria Enrica; Resnati, Chiara; Rissanen, Kari; Resnati, Giuseppe
• Is Part Of: New journal of chemistry. Volume 44:Number 47(2020)
• Page Start: 20697
• Page End: 20703
• Publication Date: 2020-11-23
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d0nj04647g
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Ebselen, a compound active against SARS-CoV-2, forms a bifurcated supramolecular synthon thanks to chalcogen bond and hydrogen bond cooperation. Abstract : Ebselen (2-phenyl-1, 2-benzoselenazol-3(2 H )one), a glutathione peroxidase mimic, is active against several RNA viruses, among others the retrovirus responsible for the COVID-19 pandemic. In this paper 77 Se and 1 H NMR studies of ebselen are reported and they identify the chalcogen bond (ChB) and hydrogen bond (HB) that are central in the landscape of interactions formed by the compound in solution. The selenium atom and the hydrogen atom at the C7 carbon act as ChB and HB donors and the O and N atoms of neutral molecules function as acceptors. The ChB and HB give rise to a bifurcated supramolecular synthon, which fastens the interaction acceptor opposite to the N–Se covalent bond of the selenazole ring. It is known that the biologically important reaction of ebselen with cysteine thiol groups is favoured when selenium acts as a chalcogen bond donor.