Raynaud's phenomenon and digital ischemia: a practical approach to risk stratification, diagnosis and management. (June 2010)

• Record Type: Journal Article
• Authors: McMahan, Zsuzsanna H; Wigley, Fredrick M
• Is Part Of: International journal of clinical rheumatology. Volume 5:Number 3(2010)
• Page Start: 355
• Page End: 370
• Publication Date: 2010-06
• Subjects: digital ischemia -- digital ulcers -- Raynaud's phenomenon -- scleroderma; Rheumatology -- Periodicals; 616.723005
• DOI: 10.2217/ijr.10.17
• Languages: English
• ISSNs: 1758-4272

Abstract

Digital ischemia is a painful and often disfiguring event. Such an ischemic event often leads to tissue loss and can significantly affect the patient's quality of life. Digital ischemia can be secondary to a vasculopathy, vasculitis, embolic disease, trauma or extrinsic vascular compression. It is an especially serious complication in patients with scleroderma. Risk stratification of patients with scleroderma at risk for digital ischemia is now possible with clinical assessment and autoantibody profiles. Because there are a variety of conditions that lead to digital ischemia, it is important to understand the pathophysiology underlying each ischemic presentation in order to target therapy appropriately. Significant progress has been made in the last 20 years in defining the pathophysiological processes leading to digital ischemia in rheumatic diseases. In this article we review the risk stratification, diagnosis and management of patients with digital ischemia and provide a practical approach to therapy, particularly in scleroderma.