Electrospinning and 3D bioprinting for intervertebral disc tissue engineering. Issue 4 (6th August 2020)

• Record Type: Journal Article
• Authors: De Pieri, Andrea; Byerley, Ann M.; Musumeci, Catherine R.; Salemizadehparizi, Fatemeh; Vanderhorst, Maya A.; Wuertz‐Kozak, Karin
• Is Part Of: JOR spine. Volume 3:Issue 4(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-08-06
• Subjects: annulus fibrosus -- bioink -- biomaterials -- endplate -- extracellular matrix -- MSCs -- nucleus pulposus -- stem cells; Spine -- Diseases -- Periodicals; Spine -- Diseases -- Treatment -- Periodicals; Spine -- Wounds and injuries -- Periodicals; Orthopedics -- Periodicals; Electronic journal; Periodicals; 616.73005
• DOI: 10.1002/jsp2.1117
• Languages: English
• ISSNs: 2572-1143

Abstract

Abstract: Intervertebral disc (IVD) degeneration is a major cause of low back pain and represents a massive socioeconomic burden. Current conservative and surgical treatments fail to restore native tissue architecture and functionality. Tissue engineering strategies, especially those based on 3D bioprinting and electrospinning, have emerged as possible alternatives by producing cell‐seeded scaffolds that replicate the structure of the IVD extracellular matrix. In this review, we provide an overview of recent advancements and limitations of 3D bioprinting and electrospinning for the treatment of IVD degeneration, focusing on future areas of research that may contribute to their clinical translation. Abstract : Tissue engineering strategies, specifially those based on electrospinning and 3D bioprinting, have the potential to produce cell‐seeded scaffolds that can replicate the structure of the IVD. Functionalization of electrospun constructs, development of novel bioink formulations, selection of suitable cell types and incorporation of beneficial cellular cues will in unison help to optimize structural, biomechanical and biological properties of tissue engineered IVDs and hopefully promote their translation into clinical practice.