Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies. (4th January 2020)

• Record Type: Journal Article
• Authors: Huang, Tao; Ding, Ming; Bergholdt Helle, K M; Wang, Tiange; Heianza, Yoriko; Sun, Dianjianyi; Frazier-Wood Alexis, C; Aslibekyan, Stella; North Kari, E; Voortman, Trudy; Graff, Mariaelisa; Smith Caren, E; Lai, Chao-Qiang; Varbo, Anette; Lemaitre, Rozenn N; de Jonge, M Ester A L; Fumeron, Frédéric; Corella, Dolores; Wang, Carol A; Tjønneland, Anne; Overvad, Kim; Sørensen, Thorkild I A; Feitosa, Mary F; Wojczynski, Mary K; Kähönen, Mika; Renström, Frida; Psaty, Bruce M; Siscovick, David S; Barroso, Inês; Johansson, Ingegerd; Hernandez, Dena; Ferrucci, Luigi; Bandinelli, Stefania; Linneberg, Allan; Zillikens, M Carola; Sandholt, Camilla Helene; Pedersen, Oluf; Hansen, Torben; Schulz, Christina-Alexandra; Sonestedt, Emily; Orho-Melander, Marju; Chen, Tzu-An; Rotter, Jerome I; Allison, Mathew A; Rich, Stephen S; Sorlí, Jose V; Coltell, Oscar; Pennell, Craig E; Eastwood, Peter; Hofman, Albert; Uitterlinden, Andre G; van Rooij, Frank J A; Chu, Audrey Y; Rose, Lynda M; Ridker, Paul M; Viikari, Jorma; Raitakari, Olli; Lehtimäki, Terho; Mikkilä, Vera; Willett, Walter C; Wang, Yujie; Tucker, Katherine L; Ordovas, Jose M; Kilpeläinen, Tuomas O; Province, Michael A; Franks, Paul W; Arnett, Donna K; Tanaka, Toshiko; Toft, Ulla; Ericson, Ulrika; Franco, Oscar H; Mozaffarian, Dariush; Hu, Frank B; Chasman, Daniel I; Nordestgaard, Børge G; Ellervik, Christina; Qi, Lu;
• Is Part Of: Clinical chemistry. Volume 64:Number 1(2018)
• Page Start: 183
• Page End: 191
• Publication Date: 2020-01-04
• Subjects: Clinical chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Biochimie -- Périodiques; Diagnostics biologiques -- Périodiques; Biochemistry; Clinical chemistry; Pharmaceutical chemistry; Biochemistry; Laboratory Techniques and Procedures; Klinische chemie; Periodicals; 616.075605
• DOI: 10.1373/clinchem.2017.280701
• Languages: English
• ISSNs: 0009-9147

Abstract

Abstract: BACKGROUND: Associations between dairy intake and body mass index (BMI) have been inconsistently observed in epidemiological studies, and the causal relationship remains ill defined. METHODS: We performed Mendelian randomization (MR) analysis using an established dairy intake-associated genetic polymorphism located upstream of the lactase gene ( LCT -13910 C/T, rs4988235) as an instrumental variable (IV). Linear regression models were fitted to analyze associations between ( a ) dairy intake and BMI, ( b ) rs4988235 and dairy intake, and ( c ) rs4988235 and BMI in each study. The causal effect of dairy intake on BMI was quantified by IV estimators among 184802 participants from 25 studies. RESULTS: Higher dairy intake was associated with higher BMI (β = 0.03 kg/m 2 per serving/day; 95% CI, 0.00–0.06; P = 0.04), whereas the LCT genotype with 1 or 2 T allele was significantly associated with 0.20 (95% CI, 0.14–0.25) serving/day higher dairy intake ( P = 3.15 × 10 −12 ) and 0.12 (95% CI, 0.06–0.17) kg/m 2 higher BMI ( P = 2.11 × 10 −5 ). MR analysis showed that the genetically determined higher dairy intake was significantly associated with higher BMI (β = 0.60 kg/m 2 per serving/day; 95% CI, 0.27–0.92; P = 3.0 × 10 −4 ). CONCLUSIONS: The present study provides strong evidence to support a causal effect of higher dairy intake on increased BMI among adults.