Two Cases of Interleukin-7–Deficient Generalized Verrucosis. (4th January 2020)

• Record Type: Journal Article
• Authors: Kosumi, Hideyuki; Natsuga, Ken; Takashima, Shota; Miyauchi, Toshinari; Huang, Yi-Ting; Nomura, Toshifumi; Yanagi, Teruki; Huang, Hsin-Yu; Chiu, Frank Po-Chao; Chen, Peng-Chieh; Hsu, Chao-Kai; Shimizu, Hiroshi
• Is Part Of: Clinical infectious diseases. Volume 71:Number 6(2020)
• Page Start: 1561
• Page End: 1563
• Publication Date: 2020-01-04
• Subjects: generalized verrucosis -- interleukin-7 -- human papillomavirus; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciz1240
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: We report 2 generalized verrucosis (GV) patients homozygous for a novel mutation in the start codon of IL7 . Unlike the previous report in which IL-7 deficiency accompanied CD4 T lymphocytopenia, circulating CD4 T cells were not depleted in one of our patients, suggesting a GV pathogenesis other than poor T-cell development.