Mitochondrial donation — hope for families with mitochondrial DNA disease. Issue 2 (23rd June 2020)

• Record Type: Journal Article
• Authors: Craven, Lyndsey; Murphy, Julie L.; Turnbull, Doug M.
• Editors: Reece, Richard
• Is Part Of: Emerging topics in life sciences. Volume 4:Issue 2(2020)
• Page Start: 151
• Page End: 154
• Publication Date: 2020-06-23
• Subjects: mitochondrial DNA disease -- mitochondrial donation -- mtDNA; Life sciences -- Periodicals; 570.5
• DOI: 10.1042/ETLS20190196
• Languages: English
• ISSNs: 2397-8554

Abstract

Abstract : In 2015, the UK became the first country to approve the use of mitochondrial donation. This novel in vitro fertilisation treatment was developed to prevent transmission of mitochondrial DNA (mtDNA) disease and ultimately give more reproductive choice to women at risk of having severely affected offspring. The policy change was a major advance that surmounted many scientific, legislative and clinical challenges. Further challenges have since been addressed and there is now an NHS clinical service available to families with pathogenic mtDNA mutations that provides reproductive advice and options, and a research study to look at the outcome at 18 months of children born after mitochondrial donation.