The effect of hormones on an uncommon breast disorder pseudoangiomatous stromal hyperplasia: a case report and literature review. Issue 12 (26th December 2020)

• Record Type: Journal Article
• Authors: Hattingh, Genevieve; Ibrahim, Mariam; Robinson, Thomas; Shah, Ajay
• Is Part Of: Journal of surgical case reports. Volume 2020:Issue 12(2020)
• Publication Date: 2020-12-26
• Subjects: PASH -- progesterone -- hormone stimulation -- cytochrome p450; Surgery -- Periodicals; Surgery -- Case studies -- Periodicals; 617.005
• DOI: 10.1093/jscr/rjaa514
• Languages: English
• ISSNs: 2042-8812

Abstract

Abstract: Pseudoangiomatous stromal hyperplasia (PASH) is a benign proliferation of the breast, with few cases reported to date. While the etiology of the disease is uncertain, a prevailing theory is that PASH is hormonally responsive, especially in the presence of progesterone. Literature review shows a correlation between PASH development and oral contraceptive pill (OCP) use. We report a case of a 28-year-old autistic female who underwent excision of palpable bilateral breast masses where the histology of the left breast mass identified as PASH. Our patient had a history of multiple medications including OCPs and cytochrome p450 inhibitors that could lead to an increase in progesterone levels. Thus, supporting a theory that medications, in addition to OCPs, may lead to an increased occurrence of PASH in pre-menopausal women.