A DNA Damage-Repair Dynamic Model for HRS/IRR Effects of C.elegans Induced by Neutron Irradiation. Issue 1 (11th March 2021)

• Record Type: Journal Article
• Authors: Feng, Guangyan; Zhang, Lianxin; Yang, Zhanguo; Zhang, Yong; Zhang, Siwei; Li, Taosheng; Xu, Zhao
• Is Part Of: Dose-response. Volume 19:Issue 1(2021)
• Publication Date: 2021-03-11
• Subjects: hyper-radiosensitivity -- neutron -- C. elegans -- surviving-fraction -- damage-repair model; Dose-response relationship (Biochemistry) -- Periodicals; Drugs -- Dose-response relationship -- Periodicals; Drugs -- Physiological effect -- Periodicals; Hormesis -- Periodicals; Dose-Response Relationship, Drug -- Periodicals; Dose-response relationship (Biochemistry); Drugs -- Dose-response relationship; Drugs -- Physiological effect; Periodicals; 571.634
• DOI: 10.1177/15593258211001254
• Languages: English
• ISSNs: 1559-3258

Abstract

Neutron irradiation which could trigger severe biological effects, is being applied in nuclear plants, radiotherapy, and aerospace gradually. Low dose hyper-radiosensitivity response of low Linear Energy Transfer (LET) irradiation on the cell survival has become a matter of great interest since its discovery, but a few research have been done on this response induced by neutron irradiation. To investigate this response induced by neutron irradiation, Caenorhabditis elegans ( C. elegans ) was irradiated by neutron irradiation. The surviving fraction of C. elegans on the 12th day after irradiation was analyzed, which showed a hyper-radiosensitive response at low doses and followed by an increase in survival fraction at slightly higher doses. The finding of this work that neutron irradiation decreased the surviving fraction in a non-dose-dependent manner was different from previous low-LET irradiation studies. To understand the experimental results, a DNA damage-repair model was introduced. By comparing experimental results with theoretical analyses, we suggest that the low dose hyper-radiosensitivity response of neutron irradiation may possible related to different radiation types and DNA damage recognition proteins and immune system of C. elegans.