Multidrug Resistance: In Situ shRNA Synthesis on DNA–Polylactide Nanoparticles to Treat Multidrug Resistant Breast Cancer (Adv. Mater. 10/2018). Issue 10 (6th March 2018)

• Record Type: Journal Article
• Authors: Ni, Qianqian; Zhang, Fuwu; Zhang, Yunlei; Zhu, Guizhi; Wang, Zhe; Teng, Zhaogang; Wang, Chunyan; Yung, Bryant C.; Niu, Gang; Lu, Guangming; Zhang, Longjiang; Chen, Xiaoyuan
• Is Part Of: Advanced materials. Volume 30:Issue 10(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-03-06
• Subjects: anticancer drug delivery -- multidrug resistance -- polypeptide copolymers -- RNA nanomedicines -- rolling circle transcription; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201870064
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : In situ rolling circle transcription (RCT) is applied by Qianqian Ni and co‐workers to develop a "core–shell" microstructure. As described by Guizhi Zhu, Longjiang Zhang, Xiaoyuan Chen, and co‐workers in article number 1705737, poly(short hairpin RNA) (shRNA) is synthesized on amphiphilic DNA–polylactide (PLA) nanoparticles for co‐delivery of therapeutic shRNA and hydrophobic chemotherapeutics. Furthermore, polypeptide copolymer is used to shrink the microstructures into multifunctional nanoparticles.