Changes in Lipids and Lipoproteins after Selective LDL Apheresis (7-Year Experience). (24th January 2012)

• Record Type: Journal Article
• Authors: Kolovou Kolovou, Genovefa Genovefa; Hatzigeorgiou Hatzigeorgiou, Georgios Georgios; Mihas Mihas, Constantinos Constantinos; Gontoras Gontoras, Nikos Nikos; Litras Litras, Panagiotis Panagiotis; Devekousos Devekousos, Dimitris Dimitris; Kontodima Kontodima, Panagiota Panagiota; Sorontila Sorontila, Constantina Constantina; Bilianou Bilianou, Helen Helen; Mavrogeni Mavrogeni, Sophie Sophie
• Other Names: Lansberg Lansberg Peter J. Peter J. Academic Editor.
• Is Part Of: Cholesterol. Volume 2012(2012)
• Publication Date: 2012-01-24
• Subjects: Cholesterol -- Periodicals; Cholesterol -- Metabolism -- Periodicals; Cholesterol -- Health aspects -- Periodicals; Coronary heart disease -- Prevention -- Periodicals; 612.0157705
• DOI: 10.1155/2012/976578
• Languages: English
• ISSNs: 2090-1283

Abstract

Abstract : Background . The aim of the study was to investigate the changes in plasma lipids and lipoproteins and the cardiovascular events after selective LDL apheresis. Methods and Results . Two pediatric patients with familial hypercholesterolemia aged 11 and 13 years and 19 dyslipidemic adults aged 41 ± 14 years underwent direct adsorption of lipoproteins (DALI) sessions. The mean follow-up period was 47 ± 23 months. The total cholesterol (TC) values before and after treatment were 8.2 ± 2.2 and 3.1 ± 1.6 mmol/l (318 ± 86 and 122 ± 62 mg/dL), respectively. The interval mean of TC was 6.9 ± 1.9 mmol/l (268 ± 75 mg/dL). The LDL cholesterol concentrations before and after treatment were 6.6 ± 2.1 and 1.7 ± 1.1 mmol/l, (256 ± 82 mg/dL and 65 ± 41 mg/dL), respectively. The percentage of acute LDL cholesterol reduction was 75 ± 11%. Cardiovascular events were observed in seven patients. The average annual event rate was 5.51%. Conclusion . LDL apheresis is a very important therapeutic tool in managing patients at high risk for premature CAD or with aggressive CAD, despite adequate medical treatment.