Therapeutic drug monitoring of vancomycin: a guideline of the Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society. (11th July 2016)

• Record Type: Journal Article
• Authors: Ye, Zhi-Kang; Chen, Yao-Long; Chen, Ken; Zhang, Xiang-Lin; Du, Guan-Hua; He, Bei; Li, Da-Kui; Liu, You-Ning; Yang, Ke-Hu; Zhang, Ying-Yuan; Zhai, Suo-Di
• Other Names: author non-byline.; Du Guan-Hua author non-byline.; He Bei author non-byline.; Li Da-Kui author non-byline.; Liu You-Nin author non-byline.; Yang Ke-Hu author non-byline.; Zhang Xiang-Lin author non-byline.; Zhang Ying-Yuan author non-byline.; Zhai Suo-Di author non-byline.; Chen Xiao author non-byline.; Chen Yao-Long author non-byline.; Du Guang author non-byline.; Gu Jian author non-byline.; Guo Dai-Hong author non-byline.; Guo Rui-Chen author non-byline.; Hu Xin author non-byline.; Li Huan-De author non-byline.; Liu Gao-Lin author non-byline.; Lv Yuan author non-byline.; Lu Wei author non-byline.; Miao Li-Yan author non-byline.; Qu Jie-Ming author non-byline.; Sun Tie-Ying author non-byline.; Tong Rong-Sheng author non-byline.; Wang Li author non-byline.; Wang Rui author non-byline.; Wang Zhi-Guo author non-byline.; Wen Ai-Dong author non-byline.; Wu Jiu-Hong author non-byline.; Wu Xin-An author non-byline.; Xu Ying-Chun author non-byline.; Zhan Si-Yan author non-byline.; Zhang Hui-Zhi author non-byline.; Zhang Jie author non-byline.; Zhang Jing author non-byline.; Zhang Jun author non-byline.; Zhao Li-Mei author non-byline.; Zhao Rong-Sheng author non-byline.; Zhao Zhi-Gang author non-byline.; Ye Zhi-Kang author non-byline.; Chen Ken author non-byline.; Men Peng author non-byline.; Zhou Jun-Wen author non-byline.; Dong Qian-Ru author non-byline.; Xie Ran author non-byline.; Jiao Rui author non-byline.; Xu Yang author non-byline.; Zhao Xi-Lan author non-byline.; Xue Jing-Yi author non-byline.;
• Is Part Of: Journal of antimicrobial chemotherapy. Volume 71:Number 11(2016:Nov.)
• Page Start: 3020
• Page End: 3025
• Publication Date: 2016-07-11
• Subjects: Anti-infective agents -- Periodicals; Chemotherapy -- Periodicals; 615.58
• DOI: 10.1093/jac/dkw254
• Languages: English
• ISSNs: 0305-7453

Abstract

Abstract : The authors present national guidelines for China using the GRADE system for evaluating the evidence in order to guide clinicians and pharmacists in conducting therapeutic drug monitoring of vancomycin. Abstract : Background: Guideline development should be based on the quality of evidence, balance of benefits and harms, economic evaluation and patients' views and preferences. Therefore, these factors were considered in the development of a new guideline for therapeutic drug monitoring (TDM) of vancomycin. Objectives: To develop an evidence-based guideline for vancomycin TDM and to promote standardized vancomycin TDM in clinical practice in China. Methods: We referred to the WHO Handbook for Guideline Development and used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to rate the quality of evidence and grade the strength of recommendations, according to economic evaluation and patients' views and preferences. We used the GRADE Grid method to formulate the recommendations. Results: The guideline presents recommendations about who should receive vancomycin TDM, how to monitor vancomycin efficacy and renal safety, therapeutic trough concentrations, time to start initial vancomycin TDM, loading dose and how to administer and adjust the vancomycin dose. Conclusions: We developed an evidence-based guideline for vancomycin TDM, which provides recommendations for clinicians and pharmacists to conduct vancomycin TDM in China.