A phase II study evaluating the role of bortezomib in the management of relapsed acute promyelocytic leukemia treated upfront with arsenic trioxide. (14th February 2020)

• Record Type: Journal Article
• Authors: Kulkarni, Uday; Ganesan, Saravanan; Alex, Ansu Abu; Palani, Hamenth; David, Sachin; Balasundaram, Nithya; Venkatraman, Arvind; Thenmozhi, Mani; Jeyaseelan, Lakshmanan; Korula, Anu; Devasia, Anup; Abraham, Aby; Janet, Nancy Beryl; Balasubramanian, Poonkuzhali; George, Biju; Mathews, Vikram
• Is Part Of: Cancer medicine. Volume 9:Number 8(2020)
• Page Start: 2603
• Page End: 2610
• Publication Date: 2020-02-14
• Subjects: arsenic trioxide -- PML mutations -- proteasome inhibitor -- relapsed acute promyelocytic leukemia; 616.994005
• DOI: 10.1002/cam4.2883
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: The standard‐of‐care for patients with acute promyelocytic leukemia (APL) relapsing after upfront arsenic trioxide (ATO) therapy is not defined. The present study was undertaken to evaluate the safety of addition of bortezomib to ATO in the treatment of relapsed APL based on our previously reported preclinical data demonstrating synergy between these agents. This was an open label, nonrandomized, phase II, single‐center study. We enrolled 22 consecutive patients with relapsed APL. The median age was 26.5 years (interquartile range 17.5 to 41.5). The median time from initial diagnosis to relapse was 23.1 months (interquartile range 15.6 to 43.8). All patients achieved hematological remission at a median time of 45 days (range 40‐63). Nineteen patients were in molecular remission at the end of induction. Grade 3 adverse events occurred in eight instances with one patient requiring discontinuation of therapy for grade 3 neuropathy. Twelve (54.5%) patients underwent autologous transplantation (auto‐SCT) in molecular remission while the rest opted for maintenance therapy. The median follow‐up was 48 months (range 28‐56.3). Of the patients undergoing auto‐SCT, all except one was alive and relapse free at last follow‐up. Of the patients who opted for maintenance therapy, three developed a second relapse. For treatment of APL relapsing after upfront ATO therapy, addition of bortezomib to a standard ATO‐based salvage regimen is safe and effective. This trial was registered at www.clinicaltrials.gov as NCT01950611. Abstract : The standard‐of‐care for patients with acute promyelocytic leukemia (APL) relapsing after upfront arsenic trioxide (ATO) therapy is not defined. In this phase II study we demonstrate the safety of adding a proteasome inhibitor with ATO in the management of relapsed APL treated with upfront ATO. We also demonstrate the efficacy of this combination and the potential for its utilization in this setting.