Carotid Intima‐Media Thickness but Not Carotid Artery Plaque in Healthy Individuals Is Linked to Lean Body Mass. Issue 15 (6th August 2019)

• Record Type: Journal Article
• Authors: Arnold, Matthew; Linden, Andrew; Clarke, Robert; Guo, Yu; Du, Huaidong; Bian, Zheng; Wan, Eric; Yang, Meng; Wang, Liang; Chen, Yuexin; Chen, Jianwei; Long, Huajun; Gu, Qijun; Collins, Rory; Li, Liming; Chen, Zhengming; Parish, Sarah
• Other Names: Chen Junshi investigator.; Lv Jun investigator.; Peto Richard investigator.; Walters Robin investigator.; Bennett Derrick investigator.; Boxall Ruth investigator.; Bragg Fiona investigator.; Chang Yumei investigator.; Chen Yiping investigator.; Gilbert Simon investigator.; Hacker Alex investigator.; Holmes Michael investigator.; Kartsonaki Christiana investigator.; Kerosi Rene investigator.; Lancaster Garry investigator.; Lin Kuang investigator.; McDonnell John investigator.; Millwood Iona investigator.; Nie Qunhua investigator.; Yao Pang investigator.; Ryder Paul investigator.; Sansome Sam investigator.; Schmidt Dan investigator.; Sohoni Rajani investigator.; Turnbull Iain investigator.; Walters Robin investigator.; Wang Jenny investigator.; Wang Lin investigator.; Wright Neil investigator.; Yang Ling investigator.; Yang Xiaoming investigator.; Han Xiao investigator.; Hou Can investigator.; Jing Biao investigator.; Liu Chao investigator.; Lv Jun investigator.; Pei Pei investigator.; Tan Yunlong investigator.; Yu Canqing investigator.; Gao Ruqin investigator.; Li Shanpeng investigator.; Wang Shaojie investigator.; Liu Yongmei investigator.; Du Ranran investigator.; Zang Yajing investigator.; Cheng Liang investigator.; Tian Xiaocao investigator.; Zhang Hua investigator.; Zhai Yaoming investigator.; Ning Feng investigator.; Sun Xiaohui investigator.; Li Feifei investigator.; Lv Silu investigator.; Wang Junzheng investigator.; Hou Wei investigator.; Zeng Mingyuan investigator.; Jiang Ge investigator.; Yang Liqiu investigator.; He Hui investigator.; Yu Bo investigator.; Li Yanjie investigator.; Xu Qinai investigator.; Kang Quan investigator.; Wang Dan investigator.; Hu Ximin investigator.; Wang Hongmei investigator.; Chen Jinyan investigator.; Fu Yan investigator.; Fu Zhenwang investigator.; Wang Xiaohuan investigator.; Weng Min investigator.; Guo Zhendong investigator.; Wu Shukuan investigator.; Li Yilei investigator.; Li Huimei investigator.; Fu Zhifang investigator.; Wu Ming investigator.; Zhou Yonglin investigator.; Zhou Jinyi investigator.; Tao Ran investigator.; Yang Jie investigator.; Su Jian investigator.; Liu Fang investigator.; Zhang Jun investigator.; Hu Yihe investigator.; Lu Yan investigator.; Ma Liangcai investigator.; Tang Aiyu investigator.; Zhang Shuo investigator.; Jin Jianrong investigator.; Liu Jingchao investigator.; Tang Zhenzhu investigator.; Chen Naying investigator.; Huang Ying investigator.; Li Mingqiang investigator.; Meng Jinhuai investigator.; Pan Rong investigator.; Jiang Qilian investigator.; Lan Jian investigator.; Liu Yun investigator.; Wei Liuping investigator.; Zhou Liyuan investigator.; Chen Ningyu investigator.; Wang Ping investigator.; Meng Fanwen investigator.; Qin Yulu investigator.; Wang Sisi investigator.; Wu Xianping investigator.; Zhang Ningmei investigator.; Chen Xiaofang investigator.; Zhou Weiwei investigator.; Luo Guojin investigator.; Li Jianguo investigator.; Chen Xiaofang investigator.; Zhong Xunfu investigator.; Liu Jiaqiu investigator.; Sun Qiang investigator.; Ge Pengfei investigator.; Ren Xiaolan investigator.; Dong Caixia investigator.; Zhang Hui investigator.; Mao Enke investigator.; Wang Xiaoping investigator.; Wang Tao investigator.; Zhang Xi investigator.; Zhang Ding investigator.; Zhou Gang investigator.; Feng Shixian investigator.; Chang Liang investigator.; Fan Lei investigator.; Gao Yulian investigator.; He Tianyou investigator.; Sun Huarong investigator.; He Pan investigator.; Hu Chen investigator.; Zhang Xukui investigator.; Wu Huifang investigator.; He Pan investigator.; Yu Min investigator.; Hu Ruying investigator.; Wang Hao investigator.; Qian Yijian investigator.; Wang Chunmei investigator.; Xie Kaixu investigator.; Chen Lingli investigator.; Zhang Yidan investigator.; Pan Dongxia investigator.; Huang Yuelong investigator.; Chen Biyun investigator.; Yin Li investigator.; Liu Huilin investigator.; Fu Zhongxi investigator.; Xu Qiaohua investigator.; Xu Xin investigator.; Zhang Hao investigator.; Li Xianzhi investigator.; Zhang Libo investigator.; Qiu Zhe investigator.;
• Is Part Of: Journal of the American Heart Association. Volume 8:Issue 15(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-08-06
• Subjects: atherosclerosis -- carotid intima‐media thickness -- lean body mass; Heart -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; Cerebrovascular disease -- Periodicals; Cardiology -- Periodicals; 616.1
• DOI: 10.1161/JAHA.118.011919
• Languages: English
• ISSNs: 2047-9980

Abstract

Abstract : Background: Lean body mass has been identified as a key determinant of left ventricular mass and wall thickness. However, the importance of lean body mass or other body‐size measures as normative determinants of carotid intima‐media thickness (cIMT), a widely used early indicator of atherosclerosis, has not been well established. Methods and Results: Carotid artery ultrasound measurements of cIMT and carotid artery plaque burden (derived from plaque number and maximum size) and measurements of body size, including height, body mass index, weight, body fat proportion, and lean body mass ([1−body fat proportion]×weight), were recorded in 25 020 participants from 10 regions of China. Analyses were restricted to a healthy younger subset (n=6617) defined as never or long‐term ex‐regular smokers aged <60 years (mean age, 50) without previous ischemic heart disease, stroke, diabetes mellitus, or hypertension and with plasma non‐high‐density lipoprotein cholesterol <4 mmol/L. Among these 6617 participants, 86% were women (because most men smoked) and 9% had carotid artery plaque. In both women and men separately, lean body mass was strongly positively associated with cIMT, but was not associated with plaque burden: overall, each 10 kg higher lean body mass was associated with a 0.03 (95% CI, 0.03–0.04) mm higher cIMT ( P =5×10 −33 ). Fat mass, height, and other body‐size measures were more weakly associated with cIMT. Conclusions: The strong association of lean body mass with cIMT, but not with plaque burden, in healthy adults suggests a normative relationship rather than reflecting atherosclerotic pathology. Common mechanisms may underlie the associations of lean body mass with cIMT and with nonatherosclerotic vascular traits.