Duration of Elevated Heart Rate Is an Important Predictor of Exercise‐Induced Troponin Elevation. Issue 4 (18th February 2020)

• Record Type: Journal Article
• Authors: Bjørkavoll‐Bergseth, Magnus; Kleiven, Øyunn; Auestad, Bjørn; Eftestøl, Trygve; Oskal, Kay; Nygård, Martin; Skadberg, Øyvind; Aakre, Kristin Moberg; Melberg, Tor; Gjesdal, Knut; Ørn, Stein
• Is Part Of: Journal of the American Heart Association. Volume 9:Issue 4(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-02-18
• Subjects: cardiac troponins -- cardiac work -- heart rate -- physical exercise; Heart -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; Cerebrovascular disease -- Periodicals; Cardiology -- Periodicals; 616.1
• DOI: 10.1161/JAHA.119.014408
• Languages: English
• ISSNs: 2047-9980

Abstract

Abstract : Background: The precise mechanisms causing cardiac troponin (cTn) increase after exercise remain to be determined. The aim of this study was to investigate the impact of heart rate (HR) on exercise‐induced cTn increase by using sports watch data from a large bicycle competition. Methods and Results: Participants were recruited from NEEDED (North Sea Race Endurance Exercise Study). All completed a 91‐km recreational mountain bike race (North Sea Race). Clinical status, ECG, blood pressure, and blood samples were obtained 24 hours before and 3 and 24 hours after the race. Participants (n=177) were, on average, 44 years old; 31 (18%) were women. Both cTnI and cTnT increased in all individuals, reaching the highest level (of the 3 time points assessed) at 3 hours after the race ( P <0.001). In multiple regression models, the duration of exercise with an HR >150 beats per minute was a significant predictor of both cTnI and cTnT, at both 3 and 24 hours after exercise. Neither mean HR nor mean HR in percentage of maximum HR was a significant predictor of the cTn response at 3 and 24 hours after exercise. Conclusions: The duration of elevated HR is an important predictor of physiological exercise‐induced cTn elevation. Clinical Trial Registration: URL: https://www.clinicaltrials.gov/ . Unique identifier: NCT02166216.