Clinical course of human herpesvirus 6 infection in pediatric living donor liver transplantation. (3rd June 2018)

• Record Type: Journal Article
• Authors: Yasui, Toshihiro; Suzuki, Tatsuya; Yoshikawa, Tetsushi; Yatsuya, Hiroshi; Kawamura, Yoshiki; Miura, Hiroki; Hara, Fujio; Watanabe, Shunsuke; Uga, Naoko; Naoe, Atsuki
• Is Part Of: Pediatric transplantation. Volume 22:Number 7(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-06-03
• Subjects: human herpesvirus -- LDLT -- pediatric liver transplantation -- viral infection; Transplantation of organs, tissues, etc. in children -- Periodicals; 617.95408305
• DOI: 10.1111/petr.13239
• Languages: English
• ISSNs: 1397-3142

Abstract

Abstract: Differentiation between active and latent viral infection is critical for analysis of HHV‐6‐associated disease. HHV‐6 infection has been associated with several clinical manifestations; however, the precise role of HHV‐6 in pediatric LDLT remains unclear. This retrospective cohort study included 33 pediatric patients who received LDLT. All of the recipients were monitored for HHV‐6 infection using viral isolation and real‐time PCR. HHV‐6 infection was observed in 14 of 33 (42.4%) recipients, and HHV‐6B infection occurred within 2 weeks after LDLT in 10 of 14 (71.4%) recipients. HHV‐6 was isolated from 10 of 33 (30.3%) recipients. Multivariate analysis showed that independent predictors of HHV‐6B infection were age (OR 0.975; 95% CI 0.943‐0.999; P = .041), PELD (OR 1.091; P = .038), and biliary atresia (OR 16.48; P = .035). The occurrence of unexplained fever was significantly higher in recipients with HHV‐6B infection (11/14) compared with uninfected recipients (6/19) ( P = .013). Additionally, ALT levels at 8 and 9 weeks after transplantation were significantly higher in the recipients with HHV‐6B infection. Younger age, high MELD/PELD score, and biliary atresia as an underlying disease were identified as risk factors for viral infection.