Plasma Free H2S Levels are Elevated in Patients With Cardiovascular Disease. Issue 5 (23rd October 2013)

• Record Type: Journal Article
• Authors: Peter, Elvis A.; Shen, Xinggui; Shah, Shivang H.; Pardue, Sibile; Glawe, John D.; Zhang, Wayne W.; Reddy, Pratap; Akkus, Nuri I.; Varma, Jai; Kevil, Christopher G.
• Is Part Of: Journal of the American Heart Association. Volume 2:Issue 5(2013:Oct.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2013-10-23
• Subjects: coronary artery disease -- hydrogen sulfide -- nitric oxide -- peripheral arterial disease; Heart -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; Cerebrovascular disease -- Periodicals; Cardiology -- Periodicals; 616.1
• DOI: 10.1161/JAHA.113.000387
• Languages: English
• ISSNs: 2047-9980

Abstract

Abstract : Background: Hydrogen sulfide (H2 S) has been implicated in regulating cardiovascular pathophysiology in experimental models. However, there is a paucity of information regarding the levels of H2 S in health and cardiovascular disease. In this study we examine the levels of H2 S in patients with cardiovascular disease as well as bioavailability of nitric oxide and inflammatory indicators. Methods and Results: Patients over the age of 40 undergoing coronary or peripheral angiography were enrolled in the study. Ankle brachial index (ABI) measurement, measurement of plasma‐free H2 S and total nitric oxide (NO), thrombospondin‐1 (TSP‐1), Interleukin‐6 (IL‐6), and soluble intercellular adhesion molecule‐1 (sICAM‐1) levels were performed. Patients with either coronary artery disease alone (n=66), peripheral arterial disease (PAD) alone (n=13), or any vascular disease (n=140) had higher plasma‐free H2 S levels compared to patients without vascular disease (n=53). Plasma‐free H2 S did not distinguish between disease in different vascular beds; however, total NO levels were significantly reduced in PAD patients and the ratio of plasma free H2 S to NO was significantly greater in patients with PAD. Lastly, plasma IL‐6, ICAM‐1, and TSP‐1 levels did not correlate with H2 S or NO bioavailability in either vascular disease condition. Conclusions: Findings reported in this study reveal that plasma‐free H2 S levels are significantly elevated in vascular disease and identify a novel inverse relationship with NO bioavailability in patients with peripheral arterial disease. Clinical Trial Registration: URL: http://www.clinicaltrials.gov . Unique identifier: NCT01407172.