Indeterminate dendritic cell tumor in the pancreas. Issue 7 (16th July 2020)

• Record Type: Journal Article
• Authors: Sortino, Rosita; Schmid, Michael; El Baz, Yassir; Loosen, Antonia; Tarantino, Ignazio; Steffen, Thomas; Schmied, Bruno M; Abbassi, Fariba
• Is Part Of: Journal of surgical case reports. Volume 2020:Issue 7(2020)
• Publication Date: 2020-07-16
• Subjects: pancreatic cancer -- dendritic cell tumor -- indeterminate dendritic cell tumor -- histiocytic pancreatic tumor -- Langerin -- Birbeck granules; Surgery -- Periodicals; Surgery -- Case studies -- Periodicals; 617.005
• DOI: 10.1093/jscr/rjaa208
• Languages: English
• ISSNs: 2042-8812

Abstract

Abstract: Indeterminate dendritic cell tumor (IDCT) is an extremely rare hematologic neoplastic disorder with proliferation of indeterminate dendritic cells. In the vast majority of cases, IDCTs are restricted to the skin or lymph nodes. To our knowledge, we report the first case of IDCT in the pancreas. Due to the rarity of extracutaneous IDCT, guidelines or treatment recommendations addressing their management are missing. We performed a review of literature to compare our experience to the management of other extracutaneous IDCT. Histopathological examination confirms the diagnosis of IDCT in electron microscopy and/or immunohistochemistry. Specific features are the lack of Birbeck granules and the nonreaction to Langerin antibodies. Concerning the aftercare of extracutaneous IDCT, we recommend a dermatological examination to rule out an additional cutaneous manifestation as well as annual blood examinations due to the association between IDCT and hematologic malignancies.