A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata. Issue 1 (2nd January 2021)

• Record Type: Journal Article
• Authors: Lam, Sio-Hong; Jian, Shu-Duan; Hwang, Tsong-Long; Chen, Po-Jen; Hung, Hsin-Yi; Kuo, Ping-Chung; Wu, Tian-Shung
• Is Part Of: Natural product research. Volume 35:Issue 1(2021)
• Page Start: 17
• Page End: 24
• Publication Date: 2021-01-02
• Subjects: Menispermaceae -- anti-inflammatory -- superoxide anion generation -- elastase release; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1611809
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new dimeric quaternary protoberberine alkaloid, bispalmatrubine (1 ), and thirteen known compounds (2 -14 ) were purified from the tubers of Tinospora dentata . Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N -formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release. GRAPHICAL ABSTRACT: