Syn-2, 3-diols and anti-inflammatory indole derivatives from Streptomyces sp. CB09001. Issue 1 (2nd January 2021)

• Record Type: Journal Article
• Authors: Jiang, Lin; Pu, Hong; Qin, Xiangjing; Liu, Jianxin; Wen, Zhongqing; Huang, Yimin; Xiang, Jingxi; Xiang, Yunxi; Ju, Jianhua; Duan, Yanwen; Huang, Yong
• Is Part Of: Natural product research. Volume 35:Issue 1(2021)
• Page Start: 144
• Page End: 151
• Publication Date: 2021-01-02
• Subjects: Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1611812
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new natural diols, (2S, 3S, 4S)-4-methyl-1-phenylhexane-2, 3-diol (1 ) and (2S, 3S)-4-methyl-1-phenylpentane-2, 3-diol (2 ), together with five known compounds, xenocyloins B-D (3–5 ), lumichrome (6 ) and thymidine (7 ) were isolated from Streptomyces sp. CB09001. The absolute configurations of 1 and 2 were established by crystallographic structure analysis. The anti-inflammatory effects of 1–7 were also investigated in RAW246.7 murine macrophage cells stimulated by lipopolysaccharide. The indole derivative xenocyloin B (3 ) significantly inhibited inducible nitric oxide synthase expression in RAW264.7 cells and could be a potential anti-inflammatory drug lead. Graphical Abstract: