Poly(d, l-lactide-co-glycolide) nanospheres within composite poly(vinyl alcohol)/aloe vera electrospun nanofiber as a novel wound dressing for controlled release of drug. Issue 4 (4th March 2021)

• Record Type: Journal Article
• Authors: Bootdee, Kittima; Nithitanakul, Manit
• Is Part Of: International journal of polymeric materials. Volume 70:Issue 4(2021)
• Page Start: 223
• Page End: 230
• Publication Date: 2021-03-04
• Subjects: Aloe vera -- antibacterial -- composite -- drug release -- electrospinning -- nanofiber -- PLGA nanosphere -- polyvinyl alcohol -- wound dressing; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2019.1706512
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: In this paper, poly(d, l -lactide-co-glycolide) (PLGA) nanospheres loading with a protein drug were incorporated in poly(vinyl alcohol)/Aloe vera (PVA/AV) nanofibers by electrospinning as a novel wound dressing. The influence of AV and PLGA nanospheres on the physical characteristics, antibacterial activity, and drug release behavior of the composite nanofibers were studied. A successful composite nanofiber production was observed by scanning electron microscopy. The release behavior showed a prolonged release with the addition of PLGA nanospheres. Antimicrobial activities against Staphylococcus aureus and Escherichia coli were found with AV content. The results indicated that the PVA/AV/PLGA nanofibers warrant further attention for wound-healing applications. Graphical Abstract: