A Rh(ii)/phosphoric acid co-catalyzed three-component reaction of diazo-ketones with alcohols and azonaphthalenes: access to indole derivatives via a formal [3 + 2]-cycloaddition. Issue 48 (10th December 2020)

• Record Type: Journal Article
• Authors: Yin, Xinru; Xu, Aimin; Hu, Jidi; Bao, Ming; Hu, Wenhao; Qian, Yu
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 48(2020)
• Page Start: 9805
• Page End: 9809
• Publication Date: 2020-12-10
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob02189j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Rh(ii )/Phosphoric Acid co-catalyzed muti-component annulation was well established as a new efficient route to construct 1-amino-indole derivatives via dearomatization/rearomatization/cyclization process with in situ formed oxonium ylide. Abstract : A novel dearomatization/rearomatization/cyclization oxonium ylide trapping process is well developed via a dirhodium(ii ) acetate and phosphoric acid cooperatively catalyzed multi-component reaction of diazo-ketones with alcohols and azonaphthalenes. This protocol provides an efficient route to synthesize N -substituted 1-amino-indole derivatives in good yield under mild reaction conditions.