Synthetic methods for compounds containing fluoro-lactam units. Issue 48 (25th November 2020)

• Record Type: Journal Article
• Authors: Wang, Xin; Lei, Jia; Li, Guofeng; Meng, Jianping; Li, Chen; Li, Jiazhu; Sun, Kai
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 48(2020)
• Page Start: 9762
• Page End: 9774
• Publication Date: 2020-11-25
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob02168g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : This review highlights recent progress in the construction of fluorinated lactams, including fluoro-β-lactams, fluoro-γ-lactams, and fluoro-δ-lactams, with an emphasis on the scopes, limitations and mechanisms of these different reactions. Abstract : In recent years, considerable attention has been devoted to the exploration of novel synthetic methods for fluoro-lactams due to their significant biological and pharmaceutical activities. This review summarizes recently established strategies for synthesizing fluorine-substituted lactams, including fluoro-β-lactams, fluoro-γ-lactams, and fluoro-δ-lactams. Additionally, the reaction scopes, limitations, and mechanisms are discussed.