MiR-3677-3p promotes hepatocellular carcinoma progression via inhibiting GSK3β. (17th November 2020)

• Record Type: Journal Article
• Authors: Li, Yanfei; Zhou, Yajie; Ma, Linlin; Liu, Dingsheng; Dai, Zhensheng; Shen, Junwei
• Is Part Of: Acta biochimica et biophysica Sinica. Volume 52:Number 12(2020)
• Page Start: 1404
• Page End: 1412
• Publication Date: 2020-11-17
• Subjects: miR-3677-3p -- hepatocellular carcinoma -- GSK3β -- proliferation; Biochemistry -- Periodicals; Biophysics -- Periodicals; 572.05
• DOI: 10.1093/abbs/gmaa125
• Languages: English
• ISSNs: 1672-9145

Abstract

Abstract: MicroRNAs play important roles in regulating hepatocellular carcinoma (HCC) formation, progression and metastasis. However, their functions and the underlying molecular mechanisms are still unclear. Here, we found that miR-3677-3p was highly expressed in primary tumor tissues of HCC patients. And its inhibition by using sponge in HCC cells could suppress cell proliferation significantly, but it has no effect on cell apoptosis. Through directly targeting to the 3′ untranslated region of glycogen synthase kinase 3-β (GSK3β), miR-3677-3p could inhibit GSK3β expression. Our study revealed that the miR-3677-3p/GSK3β axis may play a crucial role in HCC and miR-3677-3p may serve as a potential diagnostic biomarker or a therapeutic target for HCC.