Excretion of 19‐norandrosterone after consumption of boar meat. Issue 11 (14th November 2020)

• Record Type: Journal Article
• Authors: Hülsemann, Frank; Fußhöller, Gregor; Lehn, Christine; Thevis, Mario
• Is Part Of: Drug testing and analysis. Volume 12:Issue 11/12(2020)
• Page Start: 1581
• Page End: 1586
• Publication Date: 2020-11-14
• Subjects: boar meat -- carbon isotope ratios -- norandrosterone; Drugs -- Analysis -- Periodicals; Drug testing -- Periodicals; Chemistry, Forensic -- Periodicals; 615.1901
• DOI: 10.1002/dta.2958
• Languages: English
• ISSNs: 1942-7603

Abstract

Abstract: The consumption of the offal of noncastrated pigs can lead to the excretion of 19‐norandrosterone (NorA) in urine of humans. In doping control, GC/C/IRMS is the method of choice to differentiate between an endogenous or exogenous origin of urinary NorA. In some cases, after the consumption of wild boar offal, the δ 13 C values of urinary NorA fulfill the criteria of an adverse analytical finding due to differing food sources of boar and consumer. However, consumption of wild boar's offal is not very common in Germany, and thus, the occurrence of such an analytical finding is unlikely. In contrast, the commerce with wild boar meat has increased in Germany within the last years. Up to 20, 000 tons of wild boar meat are annually consumed. In order to probe for the probability of the occurrence of urinary NorA after consumption of wild boar meat, human urine samples were tested following the ingestion of commercially available game. In approximately half of the urine samples, traces of NorA were detected postadministration of 200 to 400 g boar meat. The highest urinary concentration was 2.9 ng/ml, and significant amounts were detected up to 9 h after the meal. δ 13 C values ranged from −18.5‰ to −23.5‰, which would have led to at least two adverse analytical findings if the samples were collected in an antidoping context. IRMS analysis on German boar tissue samples showed that δ 13 C values for wild boar's steroids are unpredictable and may vary seasonally. Abstract :