A randomized, controlled study of treatment with ojayeonjonghwan for patients with late onset hypogonadism. (1st October 2020)

• Record Type: Journal Article
• Authors: Lee, Kyu Won; Bae, Sang Rak; Jeong, Hyun Cheol; Choi, Jin Bong; Choi, Sae Woong; Bae, Woong Jin; Kim, Su Jin; Cho, Hyuk Jin; Ha, U-Syn; Hong, Sung-Hoo; Kim, Sae Woong
• Is Part Of: Aging male. Volume 23:Number 4(2020)
• Page Start: 264
• Page End: 271
• Publication Date: 2020-10-01
• Subjects: Andropause -- geriatrics -- sexual dysfunction -- antioxidants -- herbal medicine; Aging -- Periodicals; Men -- Periodicals; Gerontology -- Periodicals; Men -- Health and hygiene -- Periodicals; Aging -- periodicals; Geriatric -- periodicals; Men -- periodicals; Aged -- periodicals; Aged, 80 and over -- periodicals; 612.67
• DOI: 10.1080/13685538.2018.1480599
• Languages: English
• ISSNs: 1368-5538

Abstract

Abstract: Objectives: We investigate the effects of Ojayeonjonghwan (KH-204) in men with late-onset hypogonadism (LOH) symptoms. Material and methods: Initial PSA, testosterone, lipid profile and questionnaires about LOH-related symptoms were checked. After 8 weeks of the treatment (control or KH-204), questionnaires and serological tests were repeated to evaluate the efficacy of the agent. The changes of variables in each group and the difference between two groups were compared. Results: A total of 78 men were enrolled, and randomly assigned to the control group ( n = 39) or KH-204 group ( n = 39). Baseline characteristics of both group are comparable. AMS total score of control and KH-204 group were both improved at 8 weeks ( p = .010, <.001), and there was a statistically significant difference between the two groups (favorable in KH-204 group, p = .006). At 8 weeks, total IIEF score of control and KH-204 group were both improved, and there was no statistically significant difference in the degree of improvement between the two groups ( p = .303). There was no statistically significant difference of laboratory findings, in intra-group changes and inter-group comparisons. Conclusions: KH-204 was found to be effective in all LOH symptoms without changing of laboratory results. KH-204 may be safely used for treatment of male with LOH-related symptoms.