The relationship between erectile dysfunction severity, mean platelet volume and vitamin D levels. (2nd July 2020)

• Record Type: Journal Article
• Authors: Culha, Mehmet Gokhan; Atalay, Hasan Anil; Canat, Halil Lutfi; Alkan, Ilter; Ozbir, Sait; Can, Osman; Otunctemur, Alper
• Is Part Of: Aging male. Volume 23:Number 3(2020)
• Page Start: 173
• Page End: 178
• Publication Date: 2020-07-02
• Subjects: Erectile dysfunction -- 25-hydroxyvitamin D -- mean platelet volume -- inflammation -- endothelial dysfunction; Aging -- Periodicals; Men -- Periodicals; Gerontology -- Periodicals; Men -- Health and hygiene -- Periodicals; Aging -- periodicals; Geriatric -- periodicals; Men -- periodicals; Aged -- periodicals; Aged, 80 and over -- periodicals; 612.67
• DOI: 10.1080/13685538.2018.1459544
• Languages: English
• ISSNs: 1368-5538

Abstract

Abstract: Background: The aim of this study was to evaluate the relationship between mean platelet volume (MPV) and vitamin D levels according to ED severity. Methods: Between October 2015 and September 2017, patients who applied to the andrology outpatient clinic with an ED complaint were retrospectively reviewed. Patients with diabetes, hypertension, hyperlipidemia, malignancy, late-onset hypogonadism and smokers were not included in the study. The International Erectile Function Index-Erectile Function (IIEF-EF) questionnaire was used to assess the levels of erectile function. According to this scoring system, patients were divided into two groups. IIEF score: between 17 and 25 = mild ED (Group 1) and IIEF score between 16 and 0 = moderate–severe ED (Group 2). Blood samples of the patients were taken from antecubital vein and MPV and 25-hydroxyvitamin D [25(OH)D] levels were evaluated. Results: Ninety patients were included in the study (Group 1: n = 41, Group 2: n = 49). The mean age of the patients was 41.07 ± 8.56 and the mean body mass index (BMI) was 27.59 ± 3.91. 25(OH)D levels were found to be statistically lower in Group 2 (18.85 ± 6.09; 13.98 ± 7.10; p = .001). MPV levels were found to be statistically higher in Group 2 (10.05 ± 0.81; 10.78 ± 1.16; p = .001). Correlation between IIEF-EF scores and 25(OH)D levels was positive ( p = .03, r = 0.22). There was negative correlation between IIEF-EF scores and MPV and between 25(OH)D levels and MPV levels [ p = .003 for IIEF-EF/MPV, p = .04, r = −0.23 for 25(OH)D/MPV]. Conclusion: There is a significant positive correlation between ED severity and 25(OH)D levels and there is a significant negative correlation between ED severity and MPV levels.