Lycium chinense Mill improves hypogonadism via anti-oxidative stress and anti-apoptotic effect in old aged rat model. (1st October 2020)

• Record Type: Journal Article
• Authors: Jeong, Hyun Cheol; Jeon, Seung Hwan; Guan Qun, Zhu; Bashraheel, Fahad; Choi, Sae Woong; Kim, Su Jin; Bae, Woong Jin; Cho, Hyuk Jin; Ha, U-Syn; Hong, Sung Hoo; Lee, Ji Youl; Hong, Seong Bin; Kim, Sae Woong
• Is Part Of: Aging male. Volume 23:Number 4(2020)
• Page Start: 287
• Page End: 296
• Publication Date: 2020-10-01
• Subjects: Antioxidant -- late-onset hypogonadism -- testosterone -- goji berry -- animal model; Aging -- Periodicals; Men -- Periodicals; Gerontology -- Periodicals; Men -- Health and hygiene -- Periodicals; Aging -- periodicals; Geriatric -- periodicals; Men -- periodicals; Aged -- periodicals; Aged, 80 and over -- periodicals; 612.67
• DOI: 10.1080/13685538.2018.1498079
• Languages: English
• ISSNs: 1368-5538

Abstract

Abstract: Purpose: To evaluate the pharmacological effects of goji berry ( Lycium chinense P. Mill) in an animal model of late-onset hypogonadism (LOH). Materials and methods: Thirty 18-month-old male Sprague–Dawley (SD) rats were used as the LOH aged rat model. Rats were divided into five groups: a control group ( n = 6), low concentration goji berry extract group (150 mg/kg/day) ( n = 6), high concentration goji berry extract group (300 mg/kg/day) ( n = 6), low concentration goji berry complex extract group (150 mg/kg/day) ( n = 6), and high goji berry complex concentration extract group (300 mg/kg/day) ( n = 6). After six weeks of treatment, sperm counts and motility, serum testosterone level, androgen receptor (AR) expression, oxidative stress marker, and apoptotic factors were examined. Results: Goji berry extracts increased testosterone level to 2.07 ± 0.06 pmol/L in the goji berry 150 mg/kg group, 2.39 ± 0.08 pmol/L in the goji berry 300 mg/kg group, 2.97 ± 0.03 pmol/L in the goji berry complex 150 mg/kg group, and 3.34 ± 0.04 pmol/L in the goji berry complex 300 mg/kg group compared to 1.86 ± 0.03 pmol/L in the control group, respectively ( p < .05). AR expressions were increased in testis tissue significantly but were not significant in prostate tissue. Conclusions: Goji berry might improve LOH by reversing testicular dysfunction via an anti-oxidative stress mechanism without inducing prostate disease.