Epidemiology, pathogenesis and prevention of congenital cytomegalovirus infection. Issue 6 (1st December 2004)

• Record Type: Journal Article
• Authors: Burny, Wivine; Liesnard, Corinne; Donner, Catherine; Marchant, Arnaud
• Is Part Of: Expert review of anti-infective therapy. Volume 2:Issue 6(2004)
• Page Start: 881
• Page End: 894
• Publication Date: 2004-12-01
• Subjects: antibodies -- cidofovir -- congenital infection -- cytomegalovirus -- fomivirsen -- foscarnet -- ganciclovir -- pregnancy -- proteasome inhibitors -- T-lymphocytes -- vaccine -- valganciclovir; Anti-infective agents -- Research -- Periodicals; 616.90461
• DOI: 10.1586/14789072.2.6.881
• Languages: English
• ISSNs: 1478-7210

Abstract

Cytomegalovirus is the most common cause of congenital infection. Congenital cytomegalovirus infection can follow both primary and recurrent maternal infections. It is associated with a significant burden of disease and death. The determinants of mother-to-child transmission and the pathogenesis of symptomatic fetal infection remain poorly understood. For a long time, congenital cytomegalovirus infection has been a neglected disease. Recently, the Institute of Medicine has recognized that the development of a vaccine against congenital cytomegalovirus infection is a public health priority, which should stimulate research in this area. The development of antiviral therapies to prevent symptoms in infected newborns also represents an important area of research.