Histological Features of Postnatal Development of the Eye in White Rabbits. (April 2021)

• Record Type: Journal Article
• Authors: Yamagiwa, Yoshinori; Kurata, Masaaki; Satoh, Hiroshi
• Other Names: Ramos Meg Ferrell guest-editor.; Schafer Kenneth guest-editor.; Sorden Steven guest-editor.
• Is Part Of: Toxicologic pathology. Volume 49:Number 3(2021)
• Page Start: 419
• Page End: 437
• Publication Date: 2021-04
• Subjects: postnatal development -- histology -- rabbit -- eye -- drug development -- ophthalmic drug -- juvenile toxicity study; Pathology -- Periodicals; Toxicology -- Periodicals; Pathology; Toxicology; 615.9
• DOI: 10.1177/0192623320915460
• Languages: English
• ISSNs: 0192-6233

Abstract

Rabbits are frequently used in studies assessing the toxicity of ophthalmic drugs; however, the postnatal histological changes that occur in the rabbit eye have not been fully described. To characterize postnatal ocular development in white rabbits, a histological investigation of the eyes and eyelids was sequentially performed between postnatal days (PNDs) 1 and 42. The eyes opened during PNDs10 to 12. Significant changes prior to eyelid opening included the proliferation of uveal and optic nerve cells, regression of the lenticular vasculature, and thinning of the retina with a decreasing number of retinal cells. After eyelid opening, several significant changes occurred in the anterior segment, including thickening of the cornea and the development of lacrimation-related tissues in the eyelid and conjunctiva. Additionally, the differentiation of retinal layer-derived cells and optic nerve thickening occurred. The lens size continued to increase throughout the postnatal period. The histological structure of the eyes and eyelids was nearly mature by PNDs28 to 42. This study characterizes the postnatal changes in the histological features of the eyes in juvenile white rabbits, providing fundamental knowledge on the appropriate design of histological studies of the eyes in juvenile rabbits, particularly ophthalmic drug evaluations.