Cardiomyocyte ageing and cardioprotection: consensus document from the ESC working groups cell biology of the heart and myocardial function. Issue 11 (8th May 2020)

• Record Type: Journal Article
• Authors: Ruiz-Meana, Marisol; Bou-Teen, Diana; Ferdinandy, Péter; Gyongyosi, Mariann; Pesce, Maurizio; Perrino, Cinzia; Schulz, Rainer; Sluijter, Joost P G; Tocchetti, Carlo G; Thum, Thomas; Madonna, Rosalinda
• Is Part Of: Cardiovascular research. Volume 116:Issue 11(2020)
• Page Start: 1835
• Page End: 1849
• Publication Date: 2020-05-08
• Subjects: Cardiac ageing -- Cardioprotection -- Ischaemia/reperfusion injury -- Omics -- Animal models; Cardiovascular system -- Diseases -- Periodicals; Cardiovascular system -- Periodicals; 616.1
• DOI: 10.1093/cvr/cvaa132
• Languages: English
• ISSNs: 0008-6363

Abstract

Abstract: Advanced age is a major predisposing risk factor for the incidence of coronary syndromes and comorbid conditions which impact the heart response to cardioprotective interventions. Advanced age also significantly increases the risk of developing post-ischaemic adverse remodelling and heart failure after ischaemia/reperfusion (IR) injury. Some of the signalling pathways become defective or attenuated during ageing, whereas others with well-known detrimental consequences, such as glycoxidation or proinflammatory pathways, are exacerbated. The causative mechanisms responsible for all these changes are yet to be elucidated and are a matter of active research. Here, we review the current knowledge about the pathophysiology of cardiac ageing that eventually impacts on the increased susceptibility of cells to IR injury and can affect the efficiency of cardioprotective strategies.