Prostaglandin I2 mediates weak vasodilatation in human placental microvessels. Issue 6 (9th September 2020)

• Record Type: Journal Article
• Authors: Feng, Xueqin; Zhang, Yingying; Zhang, Yumeng; Yang, Xiaojun; Man, Dongmei; Lu, Likui; Xu, Ting; Liu, Yanping; Yang, Chunli; Li, Huan; Qi, Linglu; Su, Hongyu; Zhou, Xiuwen; Xu, Zhice
• Is Part Of: Biology of reproduction. Volume 103:Issue 6(2020)
• Page Start: 1229
• Page End: 1237
• Publication Date: 2020-09-09
• Subjects: placental vessels -- non-placental vessels -- PGI2 -- endothelial function -- whole K+ channels; Reproduction -- Periodicals; Biology; Reproduction; Reproduction; Electronic journals; Periodicals; Periodicals; 571.805
• DOI: 10.1093/biolre/ioaa156
• Languages: English
• ISSNs: 0006-3363

Abstract

Abstract: Human placental vessels (HPVs) play important roles in the exchange of metabolites and oxygen in maternal-fetal circulation. Endothelial-derived prostacyclin (prostaglandin I2, PGI2 ) is a critical endothelial vasodilator in the body. However, the physiological and pharmacological functions of endothelial PGI2 in the human placenta are still unclear. Human, sheep, and rat blood vessels were used in this study. Unlike non-placental vessels (non-PVs), the PGI2 synthesis inhibitor tranylcypromine (TCP) did not modify 5-hydroxytryptamine (5-HT)-induced vascular contraction, indicating that endothelial-derived PGI2 was weak in PVs. Vascular responses to exogenous PGI2 showed slight relaxation followed by a significant contraction at a higher concentration in HPV, which was inhibited by the thromboxane-prostanoid (TP) receptors antagonist SQ-29, 548. Testing PVs and non-PVs from sheep also showed similar functional results. More TP receptors than PGI2 (IP) receptors were observed in HPVs. The whole-cell K + current density of HPVs was significantly weaker than that of non-PVs. This study demonstrated the specific characteristics of the placental endogenous endothelial PGI2 system and the patterns of placental vascular physiological/pharmacological response to exogenous PGI2, showing that placental endothelial PGI2 does not markedly contribute to vascular dilation in the human placenta, in notable contrast to non-PVs. The results provide crucial information for understanding the endothelial roles of HPVs, which may be helpful for further investigations of potential targets in the treatment of diseases such as preeclampsia. Abstract : Summary sentence PGI2 dose not markedly contribute to vascular dilation in the human placenta, providing crucial information for understanding the endothelial roles in the placenta, and offering new insights into investigations of potential targets against preeclampsia.