Sustained treatment‐free remission in chronic myeloid leukaemia is associated with an increased frequency of innate CD8(+) T‐cells. (12th March 2019)

• Record Type: Journal Article
• Authors: Cayssials, Emilie; Jacomet, Florence; Piccirilli, Nathalie; Lefèvre, Lucie; Roy, Lydia; Guilhot, François; Chomel, Jean‐Claude; Leleu, Xavier; Gombert, Jean‐Marc; Herbelin, André; Barbarin, Alice
• Is Part Of: British journal of haematology. Volume 186:Number 1(2019)
• Page Start: 54
• Page End: 59
• Publication Date: 2019-03-12
• Subjects: chronic myeloid leukaemia -- tyrosine kinase inhibitors -- successful treatment discontinuation -- innate CD8(+) T‐cells -- NK cells; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.15858
• Languages: English
• ISSNs: 0007-1048

Abstract

Summary: Immunological mechanisms of treatment‐free remission (TFR) in chronic myeloid leukaemia (CML) are poorly defined and, to date, no correlation between successful TFR and CD8(+) T‐cell subsets has been found. We analysed a new identified human subset of CD8(+) T‐cells, namely innate CD8(+) T‐cells, in CML patients with TFR ≥ 2 years. We demonstrated a dramatic increase of functionally active innate CD8(+) T‐cells in these patients as compared to control subjects and patients in remission under tyrosine kinase inhibitors. Moreover, we found a positive correlation between frequencies of innate CD8(+) T‐cells and natural killer cells, possibly representing a new innate biomarker profile of successful TFR.