Outcome‐dependent geographic and individual variations in the access to renal transplantation in incident dialysed patients: a French nationwide cohort study. (6th December 2018)

• Record Type: Journal Article
• Authors: Pladys, Adélaïde; Morival, Camille; Couchoud, Cécile; Jacquelinet, Christian; Laurain, Emmanuelle; Merle, Sylvie; Vigneau, Cécile; Bayat, Sahar
• Is Part Of: Transplant international. Volume 32:Number 4(2019)
• Page Start: 369
• Page End: 386
• Publication Date: 2018-12-06
• Subjects: access to renal transplantation -- end stage renal disease -- geographical disparities -- REIN registry; Transplantation of organs, tissues, etc -- Periodicals; 617.95405
• DOI: 10.1111/tri.13376
• Languages: English
• ISSNs: 0934-0874

Abstract

Summary: This study investigated geographical variations of access to renal transplantation using three outcomes (access to the transplant waiting list, access to renal transplantation after waitlisting and access to renal transplantation after dialysis start). Associations of patient‐related and regional variables with the studied outcomes were assessed using a Cox shared frailty model and a Fine and Gray model. At the study endpoint (December 31, 2015), 26.3% of all 18–90‐year‐old patients who started dialysis in the 22 mainland and four overseas French regions in 2012 ( n = 9312) were waitlisted and 15.1% received a kidney transplant. The geographical disparities of access to renal transplantation varied according to the studied outcome. Patients from the Ile‐de‐France region had the highest probability of being waitlisted, but were less likely to receive a kidney transplant. Two regional factors were associated with the access to the waiting list and to renal transplantation from dialysis start: the incidence of preemptive kidney transplantation and of ESRD. The use of different outcomes to evaluate access to kidney transplantation could help healthcare policy‐makers to select the most appropriate interventions for each region in order to reduce treatment disparities.