Intra-mitochondrial reaction for cancer cell imaging and anti-cancer therapy by aggregation-induced emission. Issue 71 (8th December 2020)

• Record Type: Journal Article
• Authors: Kim, Sangpil; Kim, Juhee; Jana, Batakrishna; Ryu, Ja-Hyoung
• Is Part Of: RSC advances. Volume 10:Issue 71(2020)
• Page Start: 43383
• Page End: 43388
• Publication Date: 2020-12-08
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0ra07471c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Controlled intracellular chemical reactions to regulate cellular function remain a challenge in biology mimetic systems. Abstract : Controlled intracellular chemical reactions to regulate cellular functions remain a challenge in biology mimetic systems. Herein, we developed an intra-mitochondrial bio-orthogonal reaction to induce aggregation induced emission. In situ carbonyl ligation inside mitochondria drives the molecules to form nano-aggregates with green fluorescence, which leads to depolarization of the mitochondrial membrane, generation of ROS, and subsequently mitochondrial dysfunction. This intra-mitochondrial carbonyl ligation shows great potential for anticancer treatment in various cancer cell lines.