Synergistic integration of FeNi magnetic nanoparticles with graphene-based porous carbon for efficient capture of N-linked glycans. Issue 47 (8th December 2020)

• Record Type: Journal Article
• Authors: Wang, Yang; Wang, Jiaxi; Li, Jie; Ling, Yun; Jia, Yu; Yang, Yongtai; Liu, Xiaofeng; Zhang, Xiangmin; Zhou, Yaming
• Is Part Of: Nanoscale. Volume 12:Issue 47(2020)
• Page Start: 24188
• Page End: 24195
• Publication Date: 2020-12-08
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/d0nr05401a
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Ferronickel graphene-based porous carbon composites are facilely prepared, which can remarkably enrich N-linked glycans from standard bio-samples and real human serum, resulting in the successful profiling of 48 N-linked glycans in 5 μL human serum. Abstract : Developing functional porous carbon is greatly desired for the capture of N -glycans from complex bio-samples. In this work, ferronickel graphene-based porous carbon composites (FeNi–G/PC- T, T = carbonization temperature) are facilely prepared and are characterized by the synergistic integration of magnetic separation, porosity and polar interaction. Studies of capture of N-linked glycans reveal that FeNi–G/PC-800 shows a remarkable performance to enrich N-linked glycans from standard bio-samples and real human serum, resulting in the successful profiling of 48 N-linked glycans in 5 μL human serum. Structure–property relationship studies further demonstrate that the synergistically integrated FeNi nanoparticles and graphene-based porous carbon in FeNi–G/PC-800 should play a key role in the capture performance.