Clinical observation of the combined use of propofol and etomidate in painless gastroscopy. Issue 45 (6th November 2020)

• Record Type: Journal Article
• Authors: Hao, Lina; Hu, Xibei; Zhu, Bingqing; Li, Wanhong; Huang, Xiang; Kang, Fang
• Other Names: Zhang. Zongwang section editor.
• Is Part Of: Medicine. Volume 99:Issue 45(2020)
• Publication Date: 2020-11-06
• Subjects: etomidate -- painless gastroscopy -- propofol; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000023061
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Objective: This study is aims to compare the anesthetic safety of propofol combined with etomidate for painless gastroscopy. Methods: Three hundred patients undergoing painless gastroscopy were randomly assigned to P, PE1, and PE2 groups. Patients were anesthetized with propofol (P group) or propofol combined with etomidate (volume ratio 1: 1, PE1 group; volume ratio 2: 1, PE2 group). The hemodynamics and adverse reactions were observed. The sleep quality satisfaction and nature of dreams were recorded. Results: Compared with pre-anesthesia, the mean arterial pressure and heart rate of the 3 groups were significantly slower during the examination and at the end of the examination. PE1 group had a higher incidence of muscle spasm, body moving, choking, and deglutition. The incidence of hypoxemia and injection pain was higher in P group. P and PE2 group had higher sleep quality satisfaction and dream incidence after awaking. However, there was no difference in the nature of dreams among 3 groups. Conclusion: Our data indicate that the combination of 10 ml 1.0% propofol and 5 ml 0.2% etomidate for painless gastroscopy reduces adverse reactions while not affecting the patients respiratory function. Moreover, it is safe and effective, which is worthy of clinical application and promotion. Abstract : Supplemental Digital Content is available in the text