Simultaneous renal clear cell carcinoma and primary clear cell carcinoma of the liver: A case report. Issue 47 (20th November 2020)

• Record Type: Journal Article
• Authors: Jiang, Hua; Zhao, Shanchao; Li, Ganhong
• Other Names: Saranathan. Maya section editor.
• Is Part Of: Medicine. Volume 99:Issue 47(2020)
• Publication Date: 2020-11-20
• Subjects: adrenal gland -- metastasis -- primary clear cell carcinoma of the liver -- renal clear cell carcinoma; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000023263
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Rationale: Double primary clear cell carcinomas of the liver (PCCCL) and kidney are extremely rare; moreover, there have been no reported cases of adrenal metastasis from primary clear cell tumors of the liver. Patient concerns: A 47-year-old male patient was admitted to our clinic with space-occupying lesions in the left kidney and liver during a regular medical examination. Diagnoses: The tumors in the kidney and liver were diagnosed as primary clear cell carcinoma by histopathological examination. Interventions: The patient subsequently underwent nephron-sparing surgery of the left kidney and radical partial excision of the right liver lobe by laparoscopic surgery. Transcatheter arterial chemoembolization (TACE) was performed for the patient 2 weeks after tumor resection. One month after the operation, the patient started adjuvant therapy with sorafenib (400 mg twice per day orally). However, follow-up CT imaging revealed a solid mass measuring 1.9 × 2.0 × 2.0 cm 3 in the right adrenal gland at 2 months postoperatively, and then the patient underwent radiofrequency ablation (RFA) for the right adrenal tumor. Outcomes: The patient remained cancer free for 2 years following the diagnosis despite early right adrenal metastasis. Lessons: Hepatocyte immunostaining is sufficient for the diagnosis of PCCCL.