A study of 18F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia. Issue 45 (6th November 2020)

• Record Type: Journal Article
• Authors: Yassin, Mohamed A.; Nehmeh, Sadek A.; Nashwan, Abdulqadir J.; Kohla, Samah A.; Mohamed, Shehab F.; Ismail, Omar M.; Sabbagh, Ahmad Al; Ibrahim, Firyal; Soliman, Dina S.; Szabados, Lajos; Fayad, Hadi
• Is Part Of: Medicine. Volume 99:Issue 45(2020)
• Publication Date: 2020-11-06
• Subjects: fluorothymidine F-18 -- positron emission tomography -- essential thrombocythemia -- prefibrotic/early primary myelofibrosis; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000023088
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: The objectives of this research project are to study in patients with primary myelofibrosis (PMF) and Essential Thrombocythemia (ET); (1) the uptake patterns of 18 FLT-PET (FLT-PET) and its value in diagnosing, staging, and treatment response monitoring of malignant hematopoiesis, (2) compare imaging findings from FLT-PET with bone marrow biopsy (standard of care), and (3) associate FLT-PET uptake patterns with genetic makeup such as JAK2 (Janus kinase 2), CALR (Calreticulin), MPL (myeloproliferative leukemia protein), Triple negative disease, and allele burden. This trial is registered in ClinicalTrials.gov with number NCT03116542. Protocol version: Mar 2017