The Link between Thyroid Function and Depression. (14th December 2011)

• Record Type: Journal Article
• Authors: Hage Hage, Mirella P. Mirella P.; Azar Azar, Sami T. Sami T.
• Other Names: Bauer Bauer Michael Michael Academic Editor.
• Is Part Of: Journal of thyroid research. Volume 2012(2012)
• Publication Date: 2011-12-14
• Subjects: Thyroid gland -- Cancer -- Periodicals; Thyroid gland -- Diseases -- Periodicals; 616.99444
• DOI: 10.1155/2012/590648
• Languages: English
• ISSNs: 2090-8067

Abstract

Abstract : The relation between thyroid function and depression has long been recognized. Patients with thyroid disorders are more prone to develop depressive symptoms and conversely depression may be accompanied by various subtle thyroid abnormalities. Traditionally, the most commonly documented abnormalities are elevated T4 levels, low T3, elevated rT3, a blunted TSH response to TRH, positive antithyroid antibodies, and elevated CSF TRH concentrations. In addition, thyroid hormone supplements appear to accelerate and enhance the clinical response to antidepressant drugs. However, the mechanisms underlying the interaction between thyroid function and depression remain to be further clarified. Recently, advances in biochemical, genetic, and neuroimaging fields have provided new insights into the thyroid-depression relationship.