PSVII-5 Effect of maternal feed restriction at different stages of gestation on development of gastrointestinal tract of newborn goats. (30th November 2020)

• Record Type: Journal Article
• Authors: Santos, Luana; Costa, Thaís; Souza, Ranyeri; Moura, Felipe; Junior, Ivam Oliveira; Gionbelli, Tathyane; Duarte, Marcio; Gionbelli, Mateus P
• Is Part Of: Journal of animal science. Volume 98(2020)Supplement 3
• Page Start: 164
• Page End: 165
• Publication Date: 2020-11-30
• Subjects: Fetal programming -- Intestine -- Organogenesis -- Ruminants; Livestock -- Periodicals; Livestock; Electronic journals; Periodicals; 636.005
• DOI: 10.1093/jas/skaa054.291
• Languages: English
• ISSNs: 0021-8812

Abstract

Abstract: We assessed the effect of maternal feed restriction at different stages of gestation on growth and development of organs and small intestine of newborn goats. A total of 14 pregnant dams were randomly divided into one of the follow dietary treatments: Animals fed at 50% of maintenance requirement from 8-84 d of gestation and then fed at 100% maintenance requirement from day 85 of gestation to parturition (R-M, n = 6), and animals fed at 100% of maintenance requirement from 8-84 d of gestation and then fed at 50% maintenance requirement from day 85 of gestation to parturition (M-R, n = 8). At birth, newborns were slaughtered for collection of corporal components. No differences were observed among treatments for birth weight (P = 0.46). The weight of the complex reticulum-rumen-omasum tended to be heavier (P = 0.057) in the M-R group, when expressed per kg of body weight. The small intestine (P = 0.038) and total intestine (P = 0.038) were heavier in the offspring of the M-R group when expressed in kg of body weight. The M-R newborns had greater length of the small intestine (P = 0.043) and total intestine (P = 0.026). Maternal feed restriction did not influence the intestinal villi height (P = 0.406). However, newborn from R-M group had lower villus height:crypt depth ratio (P = 0.016), due to the tendency of the greater of crypt depth in these animals (P = 0.081). No differences among treatments were observed in mRNA expression of the MGAM and GLP-2R in the jejunum of the offspring (P > 0.12). Newborns of the M-R group tended to present greater mRNA abundance of the SLC5A1 (P = 0.091), SLC2A2 (P = 0.091), and OCLN (P = 0.061). In summary, restriction in the first half of gestation may be more detrimental to the performance and health of offspring throughout life due to increased impairment of intestinal development.