Diazoxide-associated pulmonary hypertension in a patient with noncompaction cardiomyopathy. (February 2021)

• Record Type: Journal Article
• Authors: Sullivan, Rachel T.; Tillman, Kathryn A.; Kindel, Steven J.; Handler, Stephanie S.
• Is Part Of: Pulmonary circulation. Volume 11:Number 1(2021)
• Publication Date: 2021-02
• Subjects: cardiomyopathy -- pediatric cardiovascular disease -- pulmonary hypertension; Pulmonary circulation -- Periodicals; Pulmonary circulation; Electronic journals -- Sciences; Periodicals; 616.24005
• DOI: 10.1177/2045894020987117
• Languages: English
• ISSNs: 2045-8932

Abstract

Development of pulmonary hypertension after initiation of diazoxide for the treatment of neonatal hyperinsulinemic hypoglycemia is a rare, but previously described association. Risk factors for development of diazoxide-associated pulmonary hypertension include lower gestational age and congenital heart disease. This novel case report describes an infant with noncompaction cardiomyopathy who developed pulmonary hypertension shortly after initiation of diazoxide for hyperinsulinemic hypoglycemia which resolved upon cessation of the drug. This case highlights the benefit of having pre-treatment knowledge of underlying cardiac anatomy and makes a case for routine echocardiographic screening for neonates initiating diazoxide treatment.