Coexisting systemic and organ-specific autoimmunity in MOG-IgG1-associated disorders versus AQP4-IgG+ NMOSD. (April 2021)

• Record Type: Journal Article
• Authors: Kunchok, Amy; Flanagan, Eoin P; Snyder, Melissa; Saadeh, Ruba; Chen, John J; Weinshenker, Brian G; McKeon, Andrew; Pittock, Sean J
• Is Part Of: Multiple sclerosis. Volume 27:Number 4(2021)
• Page Start: 630
• Page End: 635
• Publication Date: 2021-04
• Subjects: MOG-IgG-associated disorders -- AQP4-IgG neuromyelitis optica spectrum disorder -- autoimmunity -- humoral immunity -- systemic lupus erythematous; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458520933884
• Languages: English
• ISSNs: 1352-4585

Abstract

Aquaporin-4 (AQP4) neuromyelitis optica spectrum disorder (NMOSD) has been demonstrated to be associated with non-organ and organ-specific autoantibodies (antinuclear antibody, extractable nuclear antibody, double-stranded DNA, muscle acetylcholine receptor antibody) and systemic autoimmune diseases. In this study, we evaluated whether a similar association with non-organ and organ-specifc autoantibodies occurs in patients with MOG-IgG1-associated disorders. We determined that MOG-IgG1 was not strongly associated with these organ and non-organ-specific autoantibodies. Systemic lupus erythematous (SLE) was significantly associated with AQP4-IgG+ NMOSD and not with MOGAD ( p = 0.037). These findings suggest differences in co-existing systemic and organ-specific autoimmunity between MOGAD and AQP4-IgG+ NMOSD.